APLP2 Expression in Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features" and Papillary Thyroid Carcinoma

Authors

Rehab Monir Samaka, Pathology department, Faculty of medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Aiat Shaban Hemida, Pathology department, Faculty of medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Hager Abd Alnaser Alfouly, Pathology department, Faculty of medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt.Follow
Mona Abdelhamid Mohammed Kora, Pathology department, Faculty of medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt.

Abstract

Objectives: to study the expression of APLP2 in NIFTP and papillary thyroid carcinoma (PTC).

Background: The term "non-invasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) refers to a follicular thyroid neoplasm that shares morphologic characteristics with other thyroid follicular lesions, either benign or malignant nodules.

Method: 65 thyroidectomy specimens, consisting of 31 NIFTP and 34 PTC cases, were collected from the pathology department of Menoufia University's Faculty of Medicine in a period spanning between 2019 and 2022.

Results: For NIFTP, 90.3% were positive and all of PTC were positive for APLP2. The H-score values of NIFTP were higher than those of PTC, with a significant difference (P = 0.033). Overexpression of APLP2 was associated with thyroid capsular invasion in PTC and with the follicular variant of PTC (IEFVPTC).

Conclusion: APLP2 could be involved in the pathogenesis of both PTC and NIFTP.

Subject Area

Pathology

Article Type

Original Study

Recommended Citation

Samaka, Rehab Monir; Hemida, Aiat Shaban; Alfouly, Hager Abd Alnaser; and Kora, Mona Abdelhamid Mohammed (2025) "APLP2 Expression in Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features" and Papillary Thyroid Carcinoma," Menoufia Medical Journal: Vol. 38: Iss. 1, Article 29.
DOI: https://doi.org/10.59204/2314-6788.3336

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