Quality of life assessment among hypothyroid patients using translated form of Thyroid –Specific Patient Reported Outcome (ThyPRO39) questionnaire

Authors

Shimaa Kamal El Din Zewain, Internal medicine department, faculty of medicine, Menoufia University
Ghada Saeed Masoud Nagy, Internal medicine department, faculty of medicine, Menoufia UniversityFollow
Zeinab Abdel Aziz Kasemy, Public health and Community medicine department, faculty of medicine, Menoufia University
Mohammed Abd El Raouf Korany, Internal medicine department, faculty of medicine, Menoufia University
Moustafa Bakrey Hamed Ata, Internal medicine department, faculty of medicine, Menoufia University

Abstract

Background Even after attaining biochemical euthyroid status with levothyroxine (LT4) therapy, many hypothyroid patients continue experience residual hypothyroid symptoms. Objectives To assess Quality of life (QoL) in hypothyroid patients after reaching biochemical euthyroid state on Lt4 replacement therapy using Thyroid Specific Patient Reported Outcome (ThyPRO 39) questionnaire. Methods a mixed-design study was conducted with 525 participants at Menoufia University Hospital from October 2022 to March 2024. The participants were categorized into three equivalent groups of 175 participant in each one: Group C (hypothyroid) hypothyroid patients who hadn't commenced treatment; Group B (biochemical euthyroid) hypothyroid patients who underwent LT4therapy and were monitored to confirm their biochemical euthyroid status for a minimum of six months; Group A (control) participant matched for age and sex with a normal thyroid profile. All underwent comprehensive history taking, thorough physical examinations, and laboratory investigations. They completed the ThyPRO 39 questionnaire and assessed sleep efficacy and quality. Results Thyroid hormone levels, particularly TSH, are closely linked to QoL, with hypothyroid patients experiencing significant impairment. Although LT4 therapy leads to modest improvements, QoL remains diminished compared to control group. Conclusion: Quality of life was negatively impacted the hypothyroid individuals, and while LT4 replacement enhances QoL, it may not fully return to that of the control group. Furthermore, Thyroid stimulating hormone (TSH) was identified as the most significant predictor of QoL score, whereas High density lipoprotein (HDL) had the least impact.

Subject Area

Internal Medicine

Article Type

Original Study

Recommended Citation

Zewain, Shimaa Kamal El Din; Nagy, Ghada Saeed Masoud; Kasemy, Zeinab Abdel Aziz; Korany, Mohammed Abd El Raouf; and Ata, Moustafa Bakrey Hamed (2024) "Quality of life assessment among hypothyroid patients using translated form of Thyroid –Specific Patient Reported Outcome (ThyPRO39) questionnaire," Menoufia Medical Journal: Vol. 38: Iss. 1, Article 13.
DOI: https://doi.org/10.59204/2314-6788.3318

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.