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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objectives: To investigate the value of urinary Monocyte Chemoattractant Protein-1 (MCP-1) as a biomarker for lupus nephritis (LN) activity.

Background: There is a correlation between LN and increased mortality and morbidity rates, and it is more common and severe in pediatric patients.

Methods: Case-controlled study was carried out involving 30 patients with systemic lupus erythematosus (SLE) who met the 2012 revised classification criteria, along with 30 healthy controls matched for age and sex. Both groups underwent a comprehensive assessment, including detailed medical history, clinical exams, routine lab tests, MCP-1 level measurement, and, for patients with active lupus nephritis, renal biopsy.

Results: Comparing SLE patients with active LN to those without or with inactive renal disease, as well as to healthy individuals, revealed substantially higher levels of MCP-1.

Conclusion:. Measuring MCP-1 in urine appears to be a helpful non-invasive urine biomarker for identifying the degree of renal involvement in SLE. For children with SLE, checking urinary MCP-1 levels can help evaluate disease activity and assess kidney involvement.

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