Study of spinal radiographic progression in Egyptian patients with ankylosing spondylitis on different biological therapies

Authors

Maha M. Salman, Lecturer of Rheumatology, Rehabilitation and physical medicine , Faculty of Medicine, Menoufia University, Menoufia , EgyptFollow
Jehan D. Fayed, Lecturer of Rheumatology, Rehabilitation and physical medicine , Faculty of Medicine, Menoufia University, Menoufia , Egypt
Eman Ragab, Associate professor of Diagnostic Radiology Department, Faculty of Medicine, Menoufia University, Menoufia , Egypt
Asmaa A. Abdel Latif, Lecturer of Public Health and Community Medicine Department (Industrial medicine and occupational health specialty), Faculty of Medicine, Menoufia University, Menoufia , Egypt
Eman A. Galbat, Lecturer of Rheumatology, Rehabilitation and physical medicine , Faculty of Medicine, Menoufia University, Menoufia , Egypt

Subject Area

Rheumatology

Article Type

Original Study

Abstract

Background: Tumor necrosis factor inhibitors (TNFi) and interleukin-17 inhibitors (IL- 17i) are approved for treatment of ankylosing spondylitis (AS). However, their ability to retard radiographic progression remains in question. Objective: To evaluate and compare the spinal radiographic progression in Egyptian AS patients receiving either (TNFi) or (IL-17i); and its association with disease parameters. Patients and Methods: A prospective study included 60 AS biologic-naïve patients receiving TNFi (30) or IL-17i (30) evaluated before starting biologic and after 2 years. Radiographs were scored by a trained reader blinded to all data except chronology using the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured at each time point. Correlation and logistic regression analysis were done to identify risk factors and predictors of progression. Results: Both biologics significantly reduced the rate of mSASSS change but IL-17i showed a significantly lower rate (p=0.005). Both significantly reduced disease outcome measures (p

Recommended Citation

Salman, Maha M.; Fayed, Jehan D.; Ragab, Eman; Latif, Asmaa A. Abdel; and Galbat, Eman A. (2024) "Study of spinal radiographic progression in Egyptian patients with ankylosing spondylitis on different biological therapies," Menoufia Medical Journal: Vol. 37: Iss. 4, Article 23.
DOI: https://doi.org/10.59204/2314-6788.3308