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Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Background: Diabetes is an early expanding health concern that has emerged in the 21 centuries. Diabetes affects four hundred sixty-three million worldwide, depending on the International Diabetes Federation (IDF). Objectives: Measuring serum CgA levels in diabetic kidney disease patients and determine its correlation with different level of proteinuria Design: A Cross sectional research. Setting: Menoufia University Hospital Participants: 120 diabetic patients and 40 control participant. Methods: Patients were divided into 4 groups: Group I (Control group) Group II (Type 2 Diabetes-mellitus who have normo-albuminuria, Group III (Type 2 Diabetes-mellitus with micro-albuminuria) and Group IV (Type 2 Diabetes-mellitus with macroalbuminuria) Duration was from 8/2022 to 2/2023 Results: A significant positive association among serum CgA level & serum urea, serum creatinine, uric acid ,and serum cholesterol, TG, LDL, HDL and there was negative correlation between it and serum albumin. As regard univariate and multivariate recession analysis to detect risk factors for proteinuria our study shows that control of diabetes (HbA1c), systolic blood pressure, long stay of diabetes ,serum creatinine, serum low density lipoprotein and serum CgA all were risk factors for proteinuria in cases with diabetes . Conclusion: we revealed that a significant positive association among serum CgA level to detect risk factors for proteinuria. In addition, serum CgA was a risk factor for proteinuria in cases with diabetes.

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