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Subject Area

Toxicology

Article Type

Original Study

Abstract

Objectives: to evaluate the predictive factors of acute aluminum phosphide (AlP) poisoning outcome.

Background: Acute toxicity with the lethal aluminum phosphide has become a major and frequent problem in many poison control centers.

Methods: It is a prospective cohort study that was done over one year conducted on acute AlP intoxicated patients. The patients were allocated into two groups; died and survived. The socio-demographic, toxicological data and clinical evaluation were reported for each patient. Patients were subjected to laboratory investigations, electrocardiogram (ECG), echocardiogram (Echo), and oxidative biomarkers evaluation. All data were studied to estimate their associations with the patients' outcomes. A three-point prognostic scoring system for acute AlP was used as predictive value in determining differences between died and survived patients.

Results: The total number of cases was 96 patients who fulfilled the inclusion criteria, 18 patients died and 78 survived. There were no significant differences between the survived and died groups regarding the following variables: age, manner and route of exposure, gastrointestinal manifestations, baseline liver enzymes, serum electrolytes and oxidative stress biomarkers levels. Lowered Glasgow Coma Scale (score

Conclusion: Being aware of these risk factors of mortality is helpful in early, proper intervention and improving the AlP poisoning outcome.

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