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Subject Area

Surgery

Article Type

Original Study

Abstract

Objectives: This prospective observational study aimed to investigate rates of wound healing, survival analysis of wound healing time, and predictors of wound healing in patients undergoing revascularization for critical limb ischemia.

Background: Wound healing after revascularization procedures is crucial for patients with critical limb ischemia (CLI) to prevent limb loss and improve outcomes

Patients and Methods: A total of 114 patients with CLI were included in the study. Demographic data, comorbidities, laboratory investigations, tissue loss characteristics, and wound healing rates were recorded. Survival analysis of wound healing time was conducted using Kaplan-Meier curves. Multivariate sequential logistic regression was performed to identify predictors of wound healing.

Results: The median age of patients was 60 years, with a predominance of males (64.9%) and smokers (45.6%). The majority of patients had diabetes (77.2%) and underwent endovascular intervention (85.96%). Tissue loss characteristics revealed a high prevalence of gangrene (51.8%) and ulcers (42.1%). The overall wound healing rate was 43%, with a median healing duration of 112 days. Multivariate analysis identified age < 60 years, ambulatory status, and absence of wound infection as significant predictors of wound healing.

Conclusions: This study provides valuable insights into the factors associated with wound healing after revascularization for CLI. The findings underscore the importance of early intervention and targeted management strategies to optimize wound healing outcomes in this high-risk patient population. Further research is warranted to validate these findings and develop tailored approaches to improve limb salvage and patient quality of life in CLI.

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