Study the evaluation of serum Leucine-Rich Alpha-2 Glycoprotein as a biomarker for ulcerative colitis activity in ulcerative colitis patients

Authors

Heba M. El hagary, Tropical medicine department, Faculty of medicine, Menoufia University Hospital, Menoufia, Egypt.Follow
Ayman Abd Elhaleem El gamal, Associate consultant of tropical medicine, Tropical medicine department, Faculty of medicine, Menoufia University Hospital, Menoufia, Egyp
Safaa Ibrahim Tayel, Biochemistry, biochemistry Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Ahmed Abo Zaid Teima, ASS. Prof.D of tropical medicine, Tropical medicine department, Faculty of medicine, Menoufia University Hospital, Menoufia, Egypt

Subject Area

Tropical Medicine

Article Type

Original Study

Abstract

Objectives: The aim of the present research was to estimate the association of Leucine-rich alpha-2 glycoprotein (LRG) with the endoscopic and the histological activity of ulcerative colitis (UC) and if the marker can predict healing of the mucosa in comparison with the other serum & fecal markers.

Background Mucosal healing, confirmed by endoscopic evaluation, is the long-term goal of the treatment of ulcerative colitis patients (UC). Leucine-rich alpha-2 glycoprotein (LRG) is a new biomarker for monitoring the activity of the disease in ulcerative colitis patients (UC).

Patients & method: This study was conducted on 40 ulcerative colitis patients during the activity of the disease and after remission collected from gastroenterology unit and 20 controlled patients of the same age and sex. The full details regarding Leucine-Rich Alpha-2 Glycoprotein levels in these groups were discussed.

Results: There were high LRG level at UC patients in activity (208.975+ 87.458) more than those in remission (78.750+ 43.939) & the control group (54.950+ 44.414). There were positive correlation between LRG serum level and the disease activity indicators.

Conclusion: LRG serum level is a biomarker which is useful for detecting the activity of the disease and the inflammation of the mucosa in the patients who have ulcerative colitis and its reliability is more than CRP and almost equal to fecal calprotectin.

Recommended Citation

hagary, Heba M. El; gamal, Ayman Abd Elhaleem El; Tayel, Safaa Ibrahim; and Teima, Ahmed Abo Zaid (2024) "Study the evaluation of serum Leucine-Rich Alpha-2 Glycoprotein as a biomarker for ulcerative colitis activity in ulcerative colitis patients," Menoufia Medical Journal: Vol. 37: Iss. 3, Article 18.
DOI: https://doi.org/10.59204/2314-6788.3272