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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objectives: To spotlight postictal clinical, imaging and laboratory changes in epileptic children.

Background: Postictal state causes clinical, laboratory and imagings changes in epileptic children.

Methods: Ninety six children were selected in this observational study, 64 were epileptic children distributed equally among two groups of patients, as group 1(observed after 1 hour of seizure attack) and group 2 after 1 week of seizure attack. A control group of 32 patients were included fullfilling special criteria: (had no infection, chronic disease or medications) and well matched as regards age, sex and socioeconomic status. All studied children underwent some imaging studies, clinical and laboratory investigations.

Results: The mean age (8.28±4.06) and (7.77±4.56) years for epileptic (groupI and II respectively) and (8.62 ±3.30) years for control group (III). Clinical changes in group 1 such as; headache (56.3%), confusion (21.9%) autonomic and behavioral changes (65.5%) were significantly more than other two groups. Laboratory changes; for example: WBC (white blood cells) counts (10.58±3.79 *10^3) in group 1 were significantly higher other two groups (7.70±1.73*10^3), (7.07±1.37*10^3) respectively. Similarily; significant changes regarding ammonia, urea, creatininephosphokinase (CPK), cortisol, adrenocorticotropic hormone (ACTH), alaninie transferase (ALT) and serum osmolality with p values respectively (P

Conclusion: Postictal showed significant clinical, laboratory and imaging changes of epileptic children that should be followed up and further work up studies are needed to improve outcome and to predict prognosis.

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