Association of Human Platelet Alloantigen-3 Genetic Variant with Risk of Coronary Artery Disease

Authors

Suzy Salah Lasheen, Cardiology department, Faculty of Medicine, Menoufia University, Shebin elkom, Menoufia, Egypt
Mahmoud Ali Soliman, Cardiology department, Faculty of Medicine, Menoufia University, Shebin elkom, Menoufia, Egypt
Elsayed Mohamed Abdelmaged, Cardiology department, Elsahel Teaching Hospital, Cairo, EgyptFollow
Heba Mohamed Abdelallah, Clinical pathology department, National liver institute, Menoufia University, Shebin elkom, Menoufia, Egypt
Mohamed Yahia abd Alkhalik, Cardiology department, Faculty of Medicine, Menoufia University, Shebin elkom, Menoufia, Egypt

Subject Area

Cardiology

Article Type

Original Study

Abstract

Objectives: to evaluate the association of HPA-3 gene polymorphisms HPA-3 T2622G (rs5911) and the risk of CAD in Egyptian patients.

Background: Coronary artery disease (CAD) is a common cardiovascular health problem in Egypt. Genetic factors, including the human platelet alloantigen-3 (HPA-3) gene variant, play a role in CAD development.

Methods: This case control study was conducted on 95 consecutive patients referred to Menoufia University hospitals for elective coronary angiography due to positive stress test or stress imaging. The patients were properly examined, and routine laboratory investigations were done. Patients were divided into 2 groups, group 1 included patients with CAD with evidence of any luminal stenosis and group 2 included patients with normal coronaries as the control group. The Gensini score was calculated for patients of group 1 then blood sample was taken for all patients for genotyping of human platelets alloantigen polymorphisms HPA-3 T2622G (rs5911) by polymerase chain reaction (PCR) sequence specific primers.

Results: The mean age of patients in CAD group was 58.49±9.17 years and 55.96±11.41 years in control group. The frequency of diabetes mellitus (DM), dyslipidemia, family history for CAD were higher in CAD group in comparison with the control group. the frequency of the HPA-3b/3b genotype was higher in CAD patients than in those with normal coronaries. in multivariate analysis HPA 3 genetic variant remains an independent predictor for CAD.

Conclusion: This study suggests an association between CAD and the HPA-3 gene polymorphisms in Egyptian patients.

Recommended Citation

Lasheen, Suzy Salah; Soliman, Mahmoud Ali; Abdelmaged, Elsayed Mohamed; Abdelallah, Heba Mohamed; and Alkhalik, Mohamed Yahia abd (2024) "Association of Human Platelet Alloantigen-3 Genetic Variant with Risk of Coronary Artery Disease," Menoufia Medical Journal: Vol. 37: Iss. 3, Article 11.
DOI: https://doi.org/10.59204/2314-6788.3273