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Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objectives: to evaluate the utility of Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) as potential laboratory noninvasive biomarkers in colonic diseases patients Irritable bowel syndrome (IBS), Inflammatory bowel disease (IBD) and cancer colon patients. Background: IBD and cancer colon are examples of important organic intestinal diseases. IBS is one of the most common functional gastrointestinal disorders. However, some studies have shown that RDW and MPV may be demonstrated in IBS, IBD, and Colon cancer. Methods: A case control study included 300 patients have symptoms and clinical signs of colonic diseases, were diagnosed by colonoscopy examination by expert gastroenterologists, and compared to healthy controls matching in age and sex. The study was excuted in Menoufia University faculty of Medicine hospitals. Results: RDW was significantly higher, while MPV was significantly lower among IBS, IBD groups than control group. In addition, MPV was significantly lower among IBS, IBD groups than cancer colon group. PDW was significantly higher among IBS, and cancer colon groups when compared to control group. In addition, PDW was significantly lower among IBD group when compared to cancer colon group. PDW was significantly higher among IBS group when compared to IBD group. Regression analysis revealed that higher MPV could predict cancer colon on top of IBS, while higher MPV, PDW could predict cancer colon on top of IBD. Moreover, higher RDW, lower PDW could predict advanced cancer colon stage. Conclusion: RDW, MPV and PDW would be valuable diagnostic and prognostic markers in clinical practice of colonic diseases.

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