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Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objectives: The aim of our work is to study the effect of cold dialysate on dialysis adequacy and post dialysis fatigue in hemodialysis patients using dialysis recovery time as a surrogate marker of post dialysis fatigue.

Background: Adequacy of the hemodialysis refers to how well toxins and waste products are removed from the patient's blood and has a major impact on their well-being.

Patients and Methods: This is a prospective crossover study included seventy participants undergo six dialysis sessions, three sessions on cold Dialysate at 35.5°C then after one month gap another three-dialysis session on warm Dialysate at 37°C. They were evaluated for the adequacy of dialysis, B2miccrglobulin level, post-dialysis recovery time and fatigue according to piper fatigue scale(PFS).

Results: The mean age of the Participants was (43.67±14.97), (55%) of patients were males, married(61%). There was no significant difference between cold and warm dialysis regarding, Urea reduction ratio (URR) and Kt/V values(p>0.05) while there was significant reduction in B2 micrglobulin level in warm dialysate (5.60±2.33 mg/L) than cold(4.76±1.79 mg/L) post-dialysis sessions (p0.05). The PFS dimensions described a low mean value of behavioral dimension (5.70±1.40) and total scale score (5.38±1.28) in cold than warm dialysate(p>0.05).

Conclusions: Cold dialysate reduces the post-dialysis recovery time and fatigue according to piper fatigue scale while has no effect on dialysis adequacy regarding URR and Kt/V. While the warm improves B2 microglobulin elemination.

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