High Expression of Fibrinogen-Like Protein 2 Predicts Adverse Outcome for Patients with Acute Myeloid Leukemia

Authors

Amira M.F. Shehata, Clinical Pathology Department, Faculty of Medicine, Menoufia University, Menoufia, 32511. Egypt.Follow
Suzy F. Gohar, Clinical Oncology Department, Faculty of Medicine, Menoufia University, Menoufia, 32511, Egypt
Shaimaa Sherif Soliman, Public Health and Community Medicine Department, Faculty of Medicine, Menoufia University, Menoufia, 32511, Egypt.
Yasmin AHS Younis, Clinical Pathology Department, Faculty of Medicine, Menoufia University, Menoufia, 32511. Egypt.
Aliaa A. El Feshawy, Clinical Pathology Department, Faculty of Medicine, Menoufia University, Menoufia, 32511. Egypt.
Eman Mohammed Zaher, Clinical Pathology Department, Faculty of Medicine, Menoufia University, Menoufia, 32511. Egypt.

Subject Area

Hematology

Article Type

Original Study

Abstract

Objectives: To explore fibrinogen-like protein 2 (FGL2) expression in adult patients with acute myeloid leukemia (AML) and to investigate its potential clinical implication.

Background: FGL2, a key multifunctional regulatory protein, suppresses immune cells with limitation of T-cell activation. FGL2 expression is markedly increased in many cancers and is related to tumor progression and poor overall survival. AML is one of the most prevalent types of leukemia among adults. AML patients have relatively poor survival, and prompt therapy is critical. The recognition of numerous molecular modulators and the development of novel targeted therapeutics have significantly improved the outcomes for patients with AML

Patients and methods: FGL2 expression in peripheral blood mononuclear cells was measured in 42 newly diagnosed AML patients and 35 controls using quantitative reverse transcription-PCR.

Results:Our results disclosed that FGL2 was significantly overexpressed in AML patients than in control group (P

Conclusion: FGL2 may represent a novel and promising biomarker in AML prognosis.

Recommended Citation

Shehata, Amira M.F.; Gohar, Suzy F.; Soliman, Shaimaa Sherif; Younis, Yasmin AHS; El Feshawy, Aliaa A.; and Zaher, Eman Mohammed (2024) "High Expression of Fibrinogen-Like Protein 2 Predicts Adverse Outcome for Patients with Acute Myeloid Leukemia," Menoufia Medical Journal: Vol. 37: Iss. 2, Article 17.
DOI: https://doi.org/10.59204/2314-6788.3264