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Subject Area

Tropical Medicine

Article Type

Original Study

Abstract

Objectives: To assess the impact of liver injury on COVID-19 infected patients with and without pre-existing liver disease.

Background: During pandemic of COVID-19, liver injury has been reported during the disease progression. However, previous studies did not examine in detail the interaction of preexisting liver disease and COVID-19.

Methods: The current study included 583 COVID-19 patients. The participants were divided according to their hepatic condition into three groups: group I (248 patients with preexisting liver disease, which further subclassified into GIa included 64 patients with decompensated liver disease and GIb included 184 patients with compensated liver disease with an evidence of hepatic dysfunction), group II (235 patients without preexisting liver disease with an evidence of hepatic dysfunction) and group III (100 patients with normal liver functions). A clinical, laboratory and imaging initial and follow up parameters were reported and outcomes were studied.

Results: A statistically significant difference was present between groups regarding age, sex, HB, Platelets concentration and hepatic complications. There was significant correlation between patients’ need for ICU, with elevated ALT, AST and ALP (P

Conclusion: COVID-19 patients with evidence of hepatic dysfunction especially those with pre-existing liver disease had a higher morbidity and mortality rates than those with normal hepatic functions.

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