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Subject Area

Surgery

Article Type

Original Study

Abstract

Objectives: To evaluate the applicability of cell therapy using non-cultured epidermal transplantation regarding the aesthetic outcome, , and possible complications in the treatment of post-burn hypopigmentation. Background: new non-cultured autologous epidermal techniques have been developed with similar results to the cultured melanocytes techniques, but are simpler, less expensive, and less time-consuming. Methods: This prospective study was conducted on 35 post-burn hypopigmentation patients presented at the Plastic and Reconstructive Surgery Department in Menoufia University Hospitals between April 2020 to April 2023. Results: We found that the repigmentation ranged between 20-95%, and the color matching ranged between 30-80%. Most cases had good repigmentation, 60%, while 22.9% had fair repigmentation. Excellent repigmentation was detected in 14.3%, while 2.9% had poor repigmentation. There is a significant association between the development of complications and the burn site (more in the face & neck), the presence of obstacles, and the severity of the burn (more in full thickness than partial thickness burn). Also, there is a statistically significant association between the development of complications and poor outcomes in the studied cases. There is no statistically significant association between obstacles and poor outcomes in the studied patients. There is no significant correlation between the re-pigmentation% and the clinical data of the studied population. Conclusions: Cell therapy using non-cultured epidermal transplantation effectively treats post-burn hypopigmentation.

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