Prognosticimplications of Lin28, MUC1, and Lipocalin2 immunoexpression in breast cancer

Authors

Noha F. Elaidy, Departments of Pathology
Marwa M.El Mosely, Departments of PathologyFollow
Amira Elwan, Clinical Oncology
Ahmed Embaby, Internal Medicine, Zagazig University, Zagazig, Egypt
Doaa I. Abdelrahman, Departments of Pathology

Subject Area

Oncology

Article Type

Original Study

Abstract

Background

Breast carcinoma is the commonest cause of cancer-linked mortality among women worldwide.

Objectives

To assess the expression of Lin28, MUC1, and Lipocalin2 by immunohistochemistry in breast carcinoma and to investigate their correlation with clinicopathological features and patient survival.

Methods

This cross-sectional study was performed on 60formalin-fixed, paraffin-embedded tissue blocks of breast carcinoma cases. Expression patterns of Lin28, MUC1, and Lipocalin2 in breast carcinoma were investigated regarding their relation with patients̕5-year survival rate.

Results

Lin28, MUC1, and Lipocalin2 expressions were found in 55, 75, and 45% of cases, respectively. Lin28 was located in the cytoplasm, MUC1 showed membranous expression,whereas Lipocalin2 was found in both nuclei and cytoplasm of malignant cells. High expression of Lin28 and MUC1 and low expression of

Lipocalin2 were correlated with poor clinicopathological features and unfavorable overall survival in patients with breast carcinoma.

Conclusion

Lin28 and MUC1 overexpression and low Lipocalin2 expression in breast carcinoma can help in the prediction of tumor prognostication, and it can lead to the selection of patients for better treatments.

Recommended Citation

Elaidy, Noha F.; Mosely, Marwa M.El; Elwan, Amira; Embaby, Ahmed; and Abdelrahman, Doaa I. (2023) "Prognosticimplications of Lin28, MUC1, and Lipocalin2 immunoexpression in breast cancer," Menoufia Medical Journal: Vol. 36: Iss. 2, Article 9.
DOI: https://doi.org/10.59204/2314-6788.1091