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Subject Area

Cardiology

Article Type

Original Study

Abstract

Objective

The aim of this study was to evaluate the correlation between serum uric acid level and angiographic severity of coronary artery disease in patients with acute coronary syndrome (ACS).

Background

Hyperuricemia is associated with endothelial dysfunction and synthesis of free radicals that contribute to thrombus formation.

Patients and methods

This observational study was conducted in the Cardiology Department of Menoufia University Hospital and included 60 patients who were admitted withACS. Serum uric acid was measured at the time of admission. Coronary angiography was performed, and the severity of coronary artery disease was calculated by Gensini score.

Results

The mean age of the whole population was 56.52±11.68 years. The mean serum uric acid level was 7.18±2.33mg/dl. A total of 31 (51.7%) patients were normouricemic and 29 (48.3%) patients were hyperuricemic. Mean Gensini score was 37.16±14.93 in the normouricemic and 79.17±26.56 in the hyperuricemic group. There was a significant relation between serum uric acid level and the Gensini score (P

Conclusion

There was a positive correlation between serum uric acid level and the severity of coronary artery disease in patients presented with ACS.

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