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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objectives:to evaluate Pentraxin-3 Levels (PTX-3) in pediatric patients with β-thalassemia major, intermedia and minor and its relationship with antioxidant capacity and total oxidant stress.

Background: PTX-3 increases alongside with oxidant stress. Therefore, it can be used as an early diagnostic marker for inflammation.

Methods:A case control study was conducted on 60 pediatric patients with β-thalassemia enrolled from Pediatric Department, Menoufia University. Another 30age and sex matched healthy children were included as a controlgroup. The study was performed during January 2020 to January 2022.

Results: Pentraxin 3 level was higher in all β. Thalassemia patientscompared with control. Total antioxidant capacity was significantly lower in patients with β. thalassemia major versus β. thalassemia intermedia and minor. The cutoff value to detect β. Thalassemia major in pediatric patients was 2.15 ng/ml with area under curve 0.846, withsensitivity and specificity 93.3% and 63.3%. Also, the cutoff value for total antioxidant capacity was 2.11(nmol/well) with area under curve 0.695, withsensitivity and specificity 86.5% and 71.5%in relation to serum ferritin for detection of risky oxidative stress in β-thalassemia patients.

Conclusion:Pentraxin 3 level was higher in all β. Thalassemia groups compared to control. So it could be used as a marker for β. Thalassemia diagnosis. Moreover, total antioxidant capacity was significantly lower in patients with β. thalassemia major versus β. thalassemia intermedia and minor which could be used as a specific test for differentiation.

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