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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objective This study aimed to evaluate adipokines such as leptin and adiponectin in obese patients with acne vulgaris. Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit characterized by increased sebum production in response to androgens. The adipokines secreted from the sebaceous glands are considered novel factors affecting acne inflammation. Patients and methods This study was carried out at the Dermatology and Medical Biochemistry and Molecular Biology Departments of Faculty of Medicine, Menoufia University. Patients were grouped as follows: group I (patient group) included 60 obese patients with acne vulgaris, and group II (control group) included 30 healthy participants, age and sex matched with the patient group. Full history taking and complete clinical examination were done. Determination of acne vulgaris severity was done by the Global Acne Grading System. Assessment of serum leptin and adiponectin was done using enzyme linked-immunosorbent assay technique. Results There was a highly significant statistical difference between patients and controls regarding their adiponectin and leptin serum levels. The mean adiponectin level was significantly higher in patients than controls. The mean leptin was significantly lower in patients than controls. The mean disease duration was 2.63 years. The mean Global Acne Grading system was 37.7 and ranged from 7 to 71. Majority of patients had very severe form (40%), 31.7% were severe, 20% were moderate, and 8.3% were mild. Acne was related to food in 76.7% of patients. Conclusions The role of adipokines in obese patients with acne is still controversial. Adiponectin may have a role, whereas leptin may not have a role.

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