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Subject Area

Obstetrics and Gynecology

Article Type

Original Study

Abstract

Objective To investigate the association between Helicobacter pylori infection and pregnancy-induced hypertension (PIH) among pregnant women. Background PIH is a major pregnancy complication as well as a risk for maternal morbidity and mortality. It is estimated that 9.1% of maternal deaths in Africa are due to hypertensive disorders of pregnancy. H. pylori is a gram-negative bacterium. Furthermore, it was recently observed that H. pylori-seropositive patients with PIH were characterized by a more severe inflammatory status. Patients and methods A prospective study was conducted on 150 patients at the inpatient ward and outpatient clinic of the Department of Obstetrics and Gynecology, Al-Shohadaa Central Hospital, and Obstetrics and Gynecology Department, Menoufia University Hospital, during the period study from September 2020 till August 2021. Results We found that there was a highly significant difference between the studied groups regarding H. pylori, which was significantly increased among hypertensive group than nonhypertensive group. Moreover, there was a significant difference between H. pylori-positive and H. pylori-negative cases according to the degree of severity among PIH groups. Conclusion There was a direct role for H. pylori infection during pregnancy in the etiopathogenesis of PIH. In addition, there was a powerful correlation between H. pylori and grades of severity of PIH among the studied groups.

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