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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objective To assess whether the disseminated intravascular coagulation (DIC) score is more valuable than other mortality scores in predicting in-hospital mortality in septic children admitted to the pediatric intensive care unit (PICU). Background Sepsis is one of the most common causes of death among hospitalized children in the PICU. Patients and methods This prospective observational study was conducted on 96 critically ill children. Laboratory and clinical data were measured within 24 h of PICU admission. Pediatric Risk of Mortality (PRISM), Pediatric Index of Mortality II (PIM II), and Pediatric Sequential Organ Failure Assessment (pSOFA) scores were calculated. DIC score was recorded. Results The nonsurvivor group showed a highly significant increase in scores of DIC, pSOFA, PRISM, and PIM II (P = 0.005, 0.001, 0.001, and 0.001, respectively). The mechanical ventilation rate was increased in nonsurvivors than in survivors (P < 0.001). Using univariate analysis, PRISM, PIM II, pSOFA, DIC scores, and total hospital stay were predictive of mortality, and when the multivariate analysis was performed, it demonstrated that DIC score was the best predictor of hospital mortality (odds ratio = 2.11). Conclusion PRISM, PIM II, pSOFA, and DIC scores are predictive of mortality. The DIC score was the best predictor of hospital mortality among hospitalized children in the PICU.

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