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Subject Area

Dermatology

Article Type

Original Study

Abstract

Background Vitiligo represents an acquired depigmented skin disorder. Disruption of aryl hydrocarbon receptor (AhR) and cytochrome P450 1A1 (CYP1A1) is linked to a variety of skin disorders. Objectives To evaluate the expression levels of AhR and CYP1A1 in patients with vitiligo and to explore their correlation with disease activity. Patients and methods This is a case–control study that included 30 patients with vitiligo and 20 controls. All patients were assessed by vitiligo disease activity (VIDA) score for activity and vitiligo area severity index score for severity. A quantitative real-time PCR approach was used to assess AhR and CYP1A1 mRNA expressions. Results Patients with vitiligo displayed significantly decreased AhR and CYP1A1 expressions (P < 0.001) compared with the controls, with a significant positive correlation between AhR and CYP1A1 expressions (r = 0.782, P < 0.001). Moreover, there was a substantial reduction in the expression of AhR and CYP1A1 in progressive vitiligo cases compared with stationary illness cases (P < 0.001 and P = 0.003, respectively) according to the VIDA score. AhR and CYP1A1 had a significant negative connection with the VIDA score (AhR, r=−0.728, P < 0.001, and CYP1A1, r=−0.702, P < 0.001). Conclusion Lower mRNA levels of AhR and CYP1A1 might have an active role in vitiligo etiopathogenesis and could be used as predictive indicators for disease activity.

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