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Subject Area

Obstetrics and Gynecology

Article Type

Original Study

Abstract

Objective This study was conducted to assess the chemerin level and detect its role as a predictor for gestational diabetes mellitus (GDM) by studying the relation between the serum chemerin level in the first trimester and the development of GDM. Background Chemerin is an adipokine that regulates adipocyte development and metabolic function as well as glucose metabolism in liver and skeletal muscle tissue. GDM is defined as glucose intolerance first recognition during pregnancy. The incidence of GDM is increasing year by year all over the world, especially in developing countries. Patients and methods This case–control study has been conducted on a total number of 162 pregnant women during the first trimester of pregnancy, divided into two groups according to their body mass index (BMI): Group 1: normal weight and Group 2: overweight, marked or morbidly obese. Participants were selected from those attending Obstetrics and Gynecology Outpatient Clinic, Birket Al Sabaa Hospital. Based on the past review of literature that assumed the prevalence of gestational diabetes to be 13.2%, sample size has been calculated and it was 162 patients. Results Based on the current results, gestational diabetes was diagnosed among 12.3% (20 patients), 142 free gestational diabetes ones. In the present study, we found that weight and BMI were significantly higher among GDM group than non-GDM one. Elevated levels of chemerin were found among women with GDM. Conclusions Serum chemerin level measured from a single blood sample may be used as a marker for prediction of GDM specially in overweight or obese women. Weight and BMI were significantly higher among GDM group than non-GDM one.

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