•  
  •  
 

Subject Area

General Surgery

Article Type

Original Study

Abstract

Objective To assess whether MRI textural analysis could predict survival in locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (NACT). Background The current gold-standard treatment of LARC is surgery after NACT. MRI is a gold-standard tool for restaging of rectal cancer before and after NACT. Texture analysis (TA) represents a promising radiomic biomarker that can predict oncological outcomes according to tumor's MRI heterogeneity. This study hypothesizes that TA has the ability-predicting survival. Patients and methods This is a retrospective analysis of LARC patients' MRIs who received NACT. Six parameters were systematically extracted from textural histograms of post-treatment scans. The correlation between TA and overall survival was tested using Mann–Whitney U test. These parameters were then examined to determine their ability in predicting overall survival by means of Kaplan–Meier survival curves and log-rank tests. Results Two out of the six parameters extracted were significantly able to predict survival, entropy (P = 0.001), and mean of positive pixels (P < 0.001), with cutoff values of 50.265 and 5.745, respectively. Conclusions MRI textural features are potentially significant imaging biomarkers in predicting survival in LARC treated with NACT.

Download

Share

COinS