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Subject Area

Anesthesiology and Intensive Care

Article Type

Original Study

Abstract

Objectives The primary aim of the study was to show the effect of pregabalin premedication on anesthetic requirements in knee arthroscopy. The secondary aim was to study its effect on postoperative sedation, analgesia, and recovery time. Background Outpatient arthroscopic knee surgery can be performed with general or regional anesthesia. Recent data suggest that spinal and epidural anesthesia require longer discharge times than the newer shorter-acting general anesthetic drugs. Patients and methods The study was a prospective randomized controlled trial that was carried out on 112 patients admitted to Orthopaedic Surgery Department for elective knee arthroscopy. Patients were randomly classified into two groups: group I received 150 mg of oral pregabalin 1 h before surgery and group II received a placebo tablet. All patients received total intravenous anesthesia using propofol and dexmedetomidine. Propofol infusion was titrated by 20 μg/kg/min increments whenever the entropy value was above 60 for more than 10 s. Measurements included demographic data, vital signs, entropy readings, total propofol consumption, postoperative visual analog scale, Ramsay sedation scores, and recovery time. Results Total consumption of propofol was significantly lower in group I (P = 0.0001). State entropy at 20, 25, 30, 35, and 40 min intraoperative was significantly lower in group I (P = 0.0013, 0.002, 0.001, 0.0018, and 0.011, respectively). Visual analog scale was lower in group I throughout the postoperative follow-up period (P = 0.001). Postoperative Ramsay sedation scale was significantly lower in group I 15 and 30 min postoperative (P = 0.013 and 0.042, respectively). Recovery time was significantly shorter in group I (P = 0.0012). Conclusion Pregabalin as premedication can enhance the recovery by decreasing anesthetic dose and postoperative pain.

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