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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Background Patients on hemodialysis often have gastrointestinal complications; however, it is unclear whether Helicobacter pylori infection is more prevalent in these patients. Objective To determine the incidence of H. pylori infection in pediatric patients with chronic kidney disease on regular hemodialysis and to investigate the diagnostic value of noninvasive tests [urea-breath test (UBT), stool-antigen test (SAT), and serology] in diagnosing H. pylori infection in hemodialysis patients. Patients and methods An analytical cross-sectional study was carried out on 62 children with the end-stage renal disease treated by regular-maintenance hemodialysis in the Nephrology Unit in Pediatric Department, Menoufia University Hospital, to determine the incidence of H. pylori infection in pediatric patients with chronic kidney disease on regular hemodialysis and the diagnostic value of noninvasive tests (UBT, SAT, and serology) in diagnosing H. pylori infection in hemodialysis patients. Results As regards the diagnostic value of UBT and serology in diagnosing of H. pylori, our results reported that the H. pylori antibody test and SAT detect all positive cases and 97% of negative cases and only one false-positive case, while UBT detects 65.5% of positive cases (true-positive cases) and 66.7% (22 cases) (true-negative cases). Conclusion The SAT and serological test performed better than the UBT for H. pylori diagnosis where H. pylori SAT was more sensitive and accurate than UBT.

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