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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objective To evaluate the prevalence of Helicobacter pylori infection among children diagnosed as having nephrotic syndrome (NS). Background NS is primarily a pediatric disorder and is 15 times more common in children than adults. H. pylori colonizes more than 50% of people worldwide. Patients and methods This prospective study was conducted on 50 children with NS admitted and followed up in the Pediatric Nephrology Unit at Menoufia University Hospital. They were screened for H. pylori by urea breath test, stool analysis (Rapid HpSA test), and serum H. pylori antibodies. The included patients were divided into two groups regarding clinical manifestations of H. pylori. Results The mean age was 8.80 ± 3.19 years, and 68% (34 cases) were males. Abdominal manifestations were more prevalent among patients with NS with H. pylori infection. The intake of NSAIDs increases the risk for H. pylori. There was a significant relation between H. pylori infection and platelet count and white blood cells among the studied patients. The diagnostic value of H. pylori stool antigen test was 100%, serum H. pylori antibodies was 90.9%, and urea breath test was 81.8%. Conclusion In the presence of unspecified abdominal pain and other gastrointestinal tract symptoms, H. pylori should be taken into consideration. Noninvasive diagnostic tests could be useful in diagnosis of H. pylori in children with NS.

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