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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objectives The aim of the current study was to study serum albumin level in critically ill children admitted to the pediatric ICU in Menoufia University hospital and its relation to the outcome. Background Hypoalbuminemia is a common feature in critically ill children in pediatric ICUs and is associated with a poor outcome. Patients and methods A cross-sectional study was conducted on 118 critically ill children from January 2021 to December 2021. All patients in the present study were subjected to detailed history, physical examination, and laboratory investigations. Pediatric Sequential Organ Failure Assessment (PSOFA), Pediatric Risk of Mortality III (PRISM III), and neutrophil percentage-to-albumin ratio (NPAR) scores were measured in the first 24 h of admission. Results Within the first 24 h of admission, 72 (61%) cases had hypoalbuminemia while during pediatric ICU admission, 84 (71.2%) cases had hypoalbuminemia. Hypoalbuminemia at admission was associated with significant higher PSOFA and NPAR scores, lower Glasgow coma scale, lower platelets count, lower Na level, and higher C-reactive protein levels while during pediatric ICU admission it was associated with significant worse final outcome, lower platelets count, lower Na level, higher PSOFA, NPAR, and PRISM III scores in comparison to the non-hypoalbuminemia group. According to the receiver operating characteristic curve study of scoring systems to predict mortality, PSOFA and NPAR scores were significantly high in the studied groups at admission while PSOFA, PRISM III, and NPAR scores were significantly high in the studied groups during pediatric ICU admission. Conclusion Hypoalbuminemia is an independent predictor of pediatric ICU mortality.

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