•  
  •  
 

Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objectives To investigate the severity, risk factors, and outcomes of acute kidney injury (AKI) in hospitalized patients with coronavirus disease 2019 (COVID-19). Background COVID-19 has been associated with elevated incidence of AKI. More search is required to confirm the role of COVID-19 as an independent risk factor for AKI. Patients and methods This retrospective cohort study included data collected from medical records, patients' follow-up, and charts of 100 patients who were diagnosed with COVID-19 infection by a positive RT-PCR assay of a specimen collected via nasopharyngeal swab between the first of December 2020 and 31 May 2021 in COVID-19 isolation wards and ICU in Benha Teaching Hospital. Results Age and BMI were significantly higher in the AKI group, but oxygen saturation was significantly lower than in the non-AKI group (P < 0.0001). AKI was significantly associated with respiratory diseases (P = 0.003), administrating immune-suppressive drugs (P = 0.042), high sequential organ failure assessment score, critical severity, and invasive respiratory support (P < 0001). D-dimer, creatinine kinase, and creatinine were significantly higher among cases with AKI, but glomerular filtration rate was significantly lower (P < 0.001). AKI was significantly associated with high mortality (P < 0.001). The severity of disease, sequential organ failure assessment score, creatinine, glomerular filtration rate, and D-dimer were significant independent predictors for AKI. Conclusion AKI is a frequent serious complication in hospitalized patients with COVID-19 and is associated with a high risk of mortality, and the severity of COVID is an independent predictor for AKI.

Download

Share

COinS