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Abstract

Objectives To investigate the severity, risk factors, and outcomes of acute kidney injury (AKI) in hospitalized patients with coronavirus disease 2019 (COVID-19). Background COVID-19 has been associated with elevated incidence of AKI. More search is required to confirm the role of COVID-19 as an independent risk factor for AKI. Patients and methods This retrospective cohort study included data collected from medical records, patients' follow-up, and charts of 100 patients who were diagnosed with COVID-19 infection by a positive RT-PCR assay of a specimen collected via nasopharyngeal swab between the first of December 2020 and 31 May 2021 in COVID-19 isolation wards and ICU in Benha Teaching Hospital. Results Age and BMI were significantly higher in the AKI group, but oxygen saturation was significantly lower than in the non-AKI group (P < 0.0001). AKI was significantly associated with respiratory diseases (P = 0.003), administrating immune-suppressive drugs (P = 0.042), high sequential organ failure assessment score, critical severity, and invasive respiratory support (P < 0001). D-dimer, creatinine kinase, and creatinine were significantly higher among cases with AKI, but glomerular filtration rate was significantly lower (P < 0.001). AKI was significantly associated with high mortality (P < 0.001). The severity of disease, sequential organ failure assessment score, creatinine, glomerular filtration rate, and D-dimer were significant independent predictors for AKI. Conclusion AKI is a frequent serious complication in hospitalized patients with COVID-19 and is associated with a high risk of mortality, and the severity of COVID is an independent predictor for AKI.

Subject Area

Internal Medicine

Article Type

Original Study

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