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Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objective To study the validity of triglyceride–glucose (TyG) index and triglyceride/high-density lipoprotein (TG/HDL) ratio as insulin resistance (IR) markers and correlating them with atherosclerotic cardiovascular disease (ASCVD). Background IR is a metabolic disorder that leads to metabolic syndrome, which is an important risk factor for ASCVD; early detection by noninvasive, easy and cheap markers is important. Patients and methods A cross-sectional study carried out on 81 participants attending to the outpatient clinic and inpatient ward in the Internal Medicine Department. Full history, physical examination, and biochemical profiles were obtained. Participants were classified according to the Framingham Wilson score into two groups: group 1 with a score of less than 5% in 10 years and group 2 with a score of more than 5% in 10 years. Framingham Wilson score is a simplified tool used to estimate the risk level of coronary artery disease over 10 years. TyG and TG/HDL as markers for IR were evaluated in comparison to Homeostasis Model Assessment for insulin resistance (HOMA-IR) and their predictive capacity of ASCVD were studied. Results Of the studied participants, 50.6% were males and 44.4% had Framingham score more than or equal to 5 (P < 0.001). Regarding TG/HDL and TyG they had the highest area under the curve (0.94 and 0.90, respectively) compared with HOMA; there was high significant positive correlation between Framingham score and both indices (P < 0.001). Conclusion The superiority of TyG and TG/HDL over HOMA in predicting ASCVD in both diabetic and nondiabetic patients, representing useful, noninvasive, and non-expensive tools for determining IR.

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