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Subject Area

Endemic and Tropical Medicine

Article Type

Original Study

Abstract

Objectives To evaluate serum adropin level and neutrophil-platelet ratio (NeuPla ratio) as predictors of ulcerative colitis (UC) activity compared with fecal calprotectin (FC). Background UC is a chronic disease characterized by periods of activity and remission. Several markers are used in detecting UC activity like FC, serum adropin, and NeuPla ratio. Patients and methods This case–control study involved 49 patients with UC and 40 healthy individuals. The NeuPla ratio was calculated from complete blood count, and serum adropin was measured using an enzyme-linked immunosorbent assay. Correlations with UC activity scores and clinical and laboratory markers were evaluated. Results According to the Mayo's score, there were 15 patients in remission, 13 mild disease, 12 moderate disease, and nine severe diseases. The NeuPla ratio was significantly higher in UC compared with controls (17.053 ± 5.537 vs. 10.732 ± 2.578). Serum adropin levels were significantly lower for UC than controls (0.162 ± 0.089 vs. 1.164 ± 0.505 ng/ml). The NeuPla ratio cutoff point for predicting UC activity was more than 18.71 and was less than or equal to 0.1302 for serum adropin. There was no marked difference between NeuPla ratio and serum adropin combination and FC in UC activity detection. Conclusion NeuPla ratio and serum adropin level are promising predictors of UC activity and a combination of both is better than the use of either of them alone without the use of invasive studies like colonoscopy.

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