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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objective This study was designed to evaluate the clinical efficacy and safety of plasma gel as a dermal-filler injection for facial rejuvenation. Background The popularity of dermal fillers has grown rapidly in the last few years for facial rejuvenation. Plasma gel is an autologous gelatinous material that is prepared from the patient's own platelet-poor plasma (PPP). Plasma gel had gained popularity in plastic surgery, orthopedic surgery, oral surgery, and various other fields. Patients and methods A cross-sectional study was carried out on 200 females more than 40 years presented with facial aging. They were divided into two main groups: group A included satisfied females with different types and grades of facial wrinkles (150 patients), and group B included unsatisfied females with different types and grades of facial wrinkles (50 patients) selected from the Outpatient Clinic of Dermatology and Venereology Department, Menoufia General and Menoufia University Hospitals, after taking a written informed consent. They were assessed clinically before treatment sessions and at the end of the follow-up period. Results All patients showed immediate significant clinical improvement after plasma-gel injection that maintained till the end of the follow-up period. This finding was confirmed by significant reduction in the mean values of Wrinkle Severity Rating Scale (WSRS) and Tear Trough Rating Scale (TTRS). Patient's satisfaction was significantly correlated with WSRS, TTRS, and absence of complication (r: 0.57, 0.63, and –0.283, respectively). The cutoff points of TTRS score and WSRS for best satisfaction were 1.2 and 0.98, respectively, with high area under the curve (0.91, 0.89, respectively). Conclusion PPP-gel injection technique is a safe treatment method for all skin types. Autologous PPP-gel injection seems to be cost-effective, safe, well-tolerated, and minimally invasive technique producing significant aesthetic correction of facial wrinkles and tear-trough deformity.

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