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Subject Area

Dermatology

Article Type

Original Study

Abstract

Background Chronic kidney disease (CKD) is known to induce a wide spectrum of cutaneous manifestations, which has been widely reported in the literature. Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin, is a protein secreted mainly by activated neutrophils. Objectives To evaluate the relation between LCN2 expression in normal skin samples with clinical parameters of CKD. Patients and methods This cross-sectional study was conducted on 20 CKD patients. All patients were subjected to history taking and complete medical examination. Punch biopsy of normal skin was taken from each patient for the detection of immunohistochemical expression of LCN2 protein. Results LCN2 was positively expressed in the skin of all CKD patients, but with no significant association with the clinical data of the patients. Conclusion Despite positive expression of LCN2 in all normal skin samples of the studied CKD cases, it seems that this expression was not related to the clinical parameters of those patients.

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