•  
  •  
 

Subject Area

Dermatology

Article Type

Original Study

Abstract

Background Iron is an essential nutrient for mammals. Accelerated loss of nutrients through hyperproliferation and desquamation from the skin in psoriasis is known. Hepcidin is a recently discovered regulator of iron homeostasis and consequently in the pathogenesis of psoriasis. This study aimed to evaluate its level in psoriasis. Objective To evaluate serum level of hepcidin in patients with psoriasis vulgaris and its relation with severity of the disease. Patients and methods A total of 20 patients (12 males and eight females) who presented to the Dermatology Clinic of Menoufia University between October 2020 and January 2021 and diagnosed clinically as having psoriasis vulgaris and 20 healthy individuals as a control group (13 males and seven females) were included in this study. The serum levels of hepcidin and ferritin were measured by the ELISA method. The serum level of iron and total iron-binding capacity were measured by the colorimetric method. Results There was a statistically significant difference between psoriasis group and control group regarding the levels of hepcidin, ferritin, iron, and total iron-binding capacity. Conclusions Measuring the level of hepcidin in psoriatic plaques will contribute to our understanding the role of iron and hepcidin in the pathogenesis of psoriasis.

Download

Share

COinS