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Subject Area

Ophthalmology

Article Type

Review

Abstract

Objectives The aim was to evaluate the disorganized inner retinal layers, the thickness of the outer retinal layer, and central foveal thickness using spectral domain optical coherence tomography as predictors of visual acuity (VA) in patients with diabetic macular edema (DME). Data sources Medline databases (PubMed and Medscape) were searched, and all materials available in the Internet. The search was performed on January 2022. Study selection The initial search presented 120 articles. The number of studies that met the inclusion criteria was 15. The articles included both sexes, diabetic patients aged 18 years old or above and capable of giving consent and having DME as evidenced clinically with a slit-lamp biomicroscopy or on optical coherence tomography scans. Data extraction If the studies did not fulfill the inclusion criteria, they were excluded. Data from each eligible study were independently abstracted in duplicate using a data collection form to capture information on study characteristics, interventions, and quantitative results reported for each outcome of interest. Data synthesis Significant data were collected. Then a structured review was performed. Finding In total, 15 potentially relevant publications were included; it was found that disorganization of the retinal inner layers seems to be the most valued predictor of function and VA. Conclusion Disorganization of the retinal inner layers seems to be the most valued predictor of function and VA followed by central retinal thickness, and then outer retinal thickness in patients with DME.

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