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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objectives To assess interferon-induced helicase 1 (IFIH1) gene rs1990760 single-nucleotide polymorphism (SNP) in vitiligo susceptibility and protection. Background Vitiligo is a common progressive autoimmune depigmenting disorder. Its pathogenesis remains elusive; however, it is linked to both genetic and nongenetic causes. The IFIH1 is a gene locus that is related to some autoimmune disorders. Patients and methods A case–control research study was done on 50 patients with vitiligo and 50 healthy controls who were age and sex matched. The IFIH1 rs1990760 genotypes of the patients were determined by real-time PCR (Taqman allelic discrimination). For the examined SNP, different genetic models were evaluated and were adjusted for age and sex. Results The patients and their controls were agreed with the Hardy–Weinberg equilibrium for the studied SNP (2q24.2, rs1990760, IFIH1, C/T). The P value was 0.777 and 0.786 for patients and controls, respectively. In terms of IFIH1 rs1990760 genotypes, alleles, or the studied genetic models, there was no statistically significant difference between cases and controls. Conclusion IFIH1 rs1990760 has no statistically significant relation with vitiligo susceptibility and protection in the current studied sample.

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