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Subject Area

Dermatology

Article Type

Original Study

Abstract

Background Heat shock proteins (HSPs) are proteins that are expressed under a variety of stresses. How stresses and HSPs affect alopecia areata (AA) is not fully understood. Objectives To evaluate the possible role of serum level of HSP70 in the pathogenesis of AA. Patients and methods The current work examined 43 individuals with AA and 40 analogous age-matched and sex-matched healthy controls. Patients underwent full history taking, clinical examination, and investigations (HSP70 serum levels using the enzyme-linked immunosorbent assay). The data were analyzed using the SPSS software. Results In the current study, among patients, serum HSP70 ranged between 3 and 135 ng/ml with a mean of 22.45 ± 25.916, while in controls, it ranged between 4 and 106 ng/ml with a mean of 21.47 ± 24.315, with no significant difference between AA patients and controls regarding their serum HSP70 level (P = 0.616). Conclusion There was no significant difference between AA patients and controls regarding their serum HSP70 level. So future research and large-scale studies on different population and ethnicities are needed for a firmer conclusion.

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