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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objective The aim of the present study was to evaluate serum irisin, in addition to fasting insulin and fasting blood glucose levels in patients with acne vulgaris (AV), and assessment of its clinical significance and relation to insulin resistance (IR). Background AV is recognized as an almost universal cutaneous disease, the third most prevalent skin disease worldwide, with the highest prevalence among adolescents, ranging between 40 and 70%. Patients and methods This study was conducted on 40 patients suffering from AV (group A) and 40 healthy individuals of matched age and sex as a control group (group B). Serum irisin level was detected by a double-antibody sandwich enzyme-linked immunosorbent assay kit for research use (Cat# 201–12–5328). While serum fasting insulin was measured by a double-antibody sandwich enzyme-linked immunosorbent assay kit for diagnostic use (Cat# E29-072) and a standard colorimetric method was used to estimate serum fasting blood glucose level. IR was calculated according to the Homeostasis Model Assessment of Insulin Resistance index: [Fasting glucose mmol/l) × Fasting serum insulin (mIU/ml)] ÷ 22.5] Results Serum irisin level was significantly lower in AV patients than in the control group (P < 0.001). It showed a significant negative correlation with IR among patients (P = 0.012). Moreover, it was decreasing significantly with the increase in disease severity (P = 0.004). Conclusion From the results of the present work, it was concluded that IR is more common among AV patients especially in patients with severe AV lesions and that could be explained by lower serum irisin levels in those patients. Since acne is a problem in adolescents, the early recognition of IR might help in better management of acne patients.

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