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Subject Area

Clinical Pathology

Article Type

Original Study

Abstract

Objective To evaluate autophagy-related gene 5 (ATG5) rs510432 T/C polymorphism in hepatocellular carcinoma (HCC) complicating chronic hepatitis C. Background HCC represents a universal health problem. Among Egyptians, it ranks the fourth common cancer. Autophagy is an evolutionarily conserved intracellular recycling system that obtains a fundamental role in maintaining metabolism and homeostasis. It was widely stated that dysregulated autophagy has been implicated in cancer development. ATG5 is a key regulator involved in autophagosome formation. Patients and methods A total of 100 participants (40 patients with HCC, 40 patients with liver cirrhosis, and 20 healthy controls) were selected, and ATG5 rs510432 genotyping was done by real-time PCR. Results No significant statistical difference was detected in the distribution of the genotypes and allele frequencies of ATG5 rs510432 polymorphism either between HCC and cirrhotic groups (P = 0.092 and 0.733, respectively) or between HCC and healthy control groups (P = 0.848 and 0.579, respectively). However, TC genotype in cirrhotic patients had statistically significantly higher ascites degree; higher bilirubin, aspartate aminotransferase, and international normalized ratio; and statistically significant lower albumin compared with CC genotype. Conclusions The current study revealed that the ATG5 rs510432 polymorphism was not associated with an increased risk of HCC in Egyptian population. However, it might have a probable role in pathogenesis of liver cell failure, cirrhosis development, and prognosis.

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