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Subject Area

Cardiology and Vascular Medicine

Article Type

Original Study

Abstract

Objective To assess different blood pressure (BP) parameters and their changes after 6-min walk test (6-MWT) in patients with heart failure with midrange ejection fraction (HFmEF) and heart failure with preserved ejection fraction (HFpEF) and correlate them with the functional capacity (FC) as assessed by 6-min walk distance (6-MWD). Background The 6-MWT reflects the daily activity of patients with HF who develop progressive limitation of FC. Patients and methods A total of 40 patients with HFmEF and 50 patients with HFpEF were enrolled. The 6-MWT was performed according to the American Thoracic Society guidelines 2002. Different BP parameters were measured before and after 6-MWT, and 6-MWD was recorded. Result The mean 6-MWD was 325.3 ± 56.84 m in all patients, 316.1 ± 61.33 m in HFmEF group, 332.66 ± 52.44 m HFpEF group. The 6-MWD and limited FC showed no significant difference between the two groups. Independent predictors of limited FC assessed by the 6-MWD were lower EF, pulse pressure (PP), and proportionate pulse pressure (PPP) and higher diastolic blood pressure in patients with HFmEF and lower EF in patients with HFpEF. Cutoff points for prediction of limited FC as assessed by 6-MWD less than 300 m included PP less than 32.5 mmHg and PPP less than 30.22% in patients with HFmEF, PP less than 37.5 mmHg and PPP less than 32.67% in patients with HFpEF, and EF less than 42.5% in all patients. Conclution A simple bedside measurement of BP parameters correlates with the FC and can predict limited FC represented by 6-MWD less than 300 m in patients with HFmEF and HFpEF.

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