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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objectives We aimed to assess the potential role of serum proadrenomedullin (pro-ADM), in the diagnosis of neonatal sepsis. Patients and methods Pro-ADM level was assessed in 100 neonates, 50 patients with neonatal sepsis (cases), and another 50 healthy controls. Neonatal sepsis was assessed using the clinical and hematological sepsis scores plus C-reactive protein, and the diagnosis was confirmed by blood culture. Results Pro-ADM and C-reactive protein were significantly higher, P value less than 0.001, in septic neonates rather than in controls. Pro-ADM levels had a powerful discrimination ability to early differentiate neonates with sepsis, at the cutoff-point value of 145 ng/ml with a sensitivity of 100% and specificity of 100% and area under the curve of 1. Conclusion Our study supports the association of neonatal sepsis and the early elevation of serum pro-ADM, which would help in early diagnosis and early initiation of appropriate therapy.

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