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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objective To evaluate YKL-40 role in acne vulgaris (AV) patients and its potential link to the disturbed lipid profile in AV. Background AV is a cutaneous chronic inflammatory disorder. YKL-40 is an inflammatory glycoprotein associated with metabolic syndrome. Patients and methods The study was done on 40 AV patients and 40 apparently healthy individuals attending the Outpatient Clinic of Dermatology Department of Menoufia University Hospitals in the period between March 2020 and January 2021. ELISA technique was used to detect YKL-40 level. Results In the present study, patients and controls were not smokers (82.5 and 80%). About 90% of patients were married. The studied patients and all controls had no systemic treatment, topical treatment, or obesity (85, 90, and 82.5%). High-density lipoprotein was significantly lower in AV patients than in the control group. Cholesterol, triglyceride, very low-density lipoprotein, and low-density lipoprotein levels were not significantly different between both groups. YKL-40 level was significantly higher in AV patients than controls. There was a significant positive correlation between YKL-40 levels with cholesterol level (P = 0.0163), triglyceride (P = 0.001), and low-density lipoprotein (P = 0.045). YKL-40 level had significant negative correlation with high-density lipoprotein level of AV cases (P = 0.008). Receiver-operating characteristic curve analysis shows that more than 9.94 ng/ml was the best cutoff for YKL-40 level to predict the risk of AV patients under an area of 0.711 with sensitivity of 82.5% and specificity of 75.0% with a statistically significant association (95% confidence interval, 0.599–0.807, P = 0.001). Conclusion It is concluded that higher YKL-40 level was considered as a predictor of AV susceptibility and higher severity.

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