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Subject Area

Clinical Pathology

Article Type

Original Study

Abstract

Objective To detect the association of tumor necrosis factor superfamily 4 (TNFSF4; rs1234315) with susceptibility of systemic lupus erythematosus (SLE) disease in gene polymorphism Egyptian patients. Background SLE is an autoimmune disease characterized by the formation of antibodies against cytoplasmic and nuclear antigens resulting in multisystem inflammatory processes. The TNFSF4 is an inflammatory factor linked to various inflammatory disorders and cancers. TNFSF4 gene has been reported to be related to SLE susceptibility because it encodes the OX40 ligand protein, which can stimulate the production of more autoantibodies. Patients and methods In this case–control study real-time PCR with allelic discrimination assay was used to genotype the TNFSF4 gene rs1234315 C/T polymorphism in 286 participants divided into two groups. Group I: 143 SLE patients fulfilling four or more criteria of the updated American College of Rheumatology criteria and group II: 143 healthy controls with matched age and sex with patients. Results The CC genotype of TNFSF4 rs1234315 was highly statistically significant in controls (P < 0.001), while TT genotype (P < 0.001) and T allele (P < 0.001) (odds ratio: 1.759; confidence interval: 1.262–2.450) were highly statistically significant in SLE patients. Conclusion There is an association of TNFSF4 (rs1234315) gene polymorphism and SLE susceptibility in Egyptian patients.

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