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Subject Area

Anesthesiology and Intensive Care

Article Type

Review

Abstract

Objectives The aim was to make a systematic review of perioperative coagulation management during liver transplantation (LT). Data sources Medline databases (PubMed and Medscape) and all materials available on the Internet were searched., The search was performed on January 2022. Study selection The initial search presented 120 articles. The number of studies that met the inclusion criteria was 23. The articles included both sexes, diagnosed patients who needed LT. Data extraction If the studies did not fulfill the inclusion criteria, they were excluded. Data from each eligible study were independently abstracted in duplicate using a data collection form to capture information on study characteristics, interventions, and quantitative results reported for each outcome of interest. Data synthesis Significant data were collected. Then a structured review was performed. Finding In total, 23 potentially relevant publications were included; it was found that early identification with clinical coagulation tests led to better understanding of coagulopathy using point-of-care viscoelastic coagulation tests as rotational thromboelastometry and thromboelastogram may improve outcomes of cirrhotic patients. Conclusion Cirrhotic patients have unstable balance of coagulation. This results in a challenge to prevent risk of bleeding or thrombosis during LT. Recently, clinical coagulation tests have led to better understanding of coagulopathy using point-of-care viscoelastic coagulation tests such as rotational thromboelastometry and thromboelastogram. Future research is needed to better understand the complex coagulation balances and to improve goal-directed transfusion and factor concentrate treatment.

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