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Subject Area

Obstetrics and Gynecology

Article Type

Original Study

Abstract

Objectives To compare the efficacy of intraumbilical oxytocin injection and sublingual misoprostol on the third stage of labor and their effects on maternal outcome. Background The most common complication accompanying the third stage is postpartum hemorrhage owing to uterine atony. WHO recommends active management of third stage, which consists of prophylactic administration of 10 IU oxytocin in 2 min after delivery of the fetus. Patients and methods This randomized trial included three groups: group 1 (control group) and two active group 2 and group 3. Group 1 had the usual active management of the third stage in the form of prophylactic administration of 10 IU of intramuscular oxytocin in 2 min after delivery of the fetus, group 2 received 10 IU oxytocin injected through umbilical vein using umbilical catheter, and group 3 received 400 μg of sublingual misoprostol after delivery of the fetus. In addition to the previous interventions, both group 2 and group 3 also had received the usual active management steps of the third stage. Results There was no significant difference in the duration of the third stage among the three groups, as P value was 0.08. There was also no significant difference in the amount of blood loss in the third stage of labor, as P value was 0.317. Conclusion The use of intraumbilical oxytocin injection or sublingual misoprostol along the third stage of labor did not lead to significant statistical reduction either along the duration of third stage or amount of blood loss.

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