•  
  •  
 

Subject Area

Pathology

Article Type

Original Study

Abstract

Objective To assess the expression of nuclear localization leucine-rich-repeat protein 1 (NLRP1) inflammasome and interleukin 1 beta (IL-1β) in lesional and perilesional skin of patients with vitiligo compared with their expression in healthy controls. Background Vitiligo is an acquired depigmentation disorder that occurs owing to destruction of melanocytes. The exact mechanisms of vitiligo have not yet been fully elucidated; however, autoimmune mechanism is most accepted one. Patients and methods This case–control study was carried out on 60 participants (30 patients with vitiligo, including lesional and perilesional vitiligo, and 30 controls) selected randomly from the outpatient dermatology clinic. Controls were selected from persons attending the plastic surgery department. Results There were highly significant differences among the three studied groups and NLRP1 and IL-1β immunohistochemical expression, as most of control group and lesional vitiligo group showed lower grade of expression (grades 1 and 2) in comparison with perilesional group. There was a statistically significant association between lesional H score of NLRP1 expression and positive family history. Moreover, there was a statistically significant difference between low-grade lesional expression of IL-1β and mild dermal inflammatory infiltrate and between low-grade IL-1β lesional expression and high vitiligo area severity index score. Conclusion The significant association between high NLRP1 and IL-1β in perilesional area of vitiligo in comparison with lesional area and control group might indicate their role in the pathogenesis and progression of active vitiligo. Moreover, it might be used as a target therapy for patients with vitiligo.

Download

Share

COinS