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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objective This work was designed to study the role of periostin in children with atopic dermatitis (AD) and to correlate its level with the severity and chronicity of AD. Background Periostin is a recent mediator in chronic states of allergic diseases and has significant roles in tissue remodeling in allergic inflammation. It has a unique function as an intrinsic mediator in amplifying and preserving allergic skin inflammation and might be a virtual molecule in the development and occurrence of chronicity. Patients and methods The current work examined 40 children with AD and 40 age- and sex-matched healthy controls. Patients underwent full history-taking, clinical examination, eosinophil count, and measurements of biochemical markers such as total immunoglobulin E and periostin by the ELISA technique. Results Serum periostin level was significantly higher in the AD group in comparison with the controls (P < 0.001), and serum periostin level was observed to have a positive correlation to SCORing-AD score (r = 0.3, P = 0.02). Moreover, a significant association existed between serum periostin level and the severity of AD; the more severe the AD, the higher the level of periostin (P = 0.01). Conclusion Serum periostin level appears to be a novel chemical biomarker to determine the severity and chronicity of AD in children.

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