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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objective The aim was to assess linkage between serum uric acid (UA) and clinical features of psoriasis. Background Psoriasis is a chronic immune-mediated skin disease. UA is an end product of purine metabolism and is produced endogenously. Patients and methods A case–control study was conducted on 100 patients with chronic generalized psoriasis (group 1) and 100 age-matched and sex-matched healthy individuals (group 2). Patients of group 1 were subdivided into three subgroups with respect to grades of psoriasis: group 1a included patients with mild psoriasis, group 1b included patients with moderate psoriasis, and group 1c included patients with severe psoriasis. In group 1, we found that there was a significant positive correlation between serum UA level and each of age, duration of disease, and psoriasis area severity index score (P = 0.023, 0.017, and 0.002, respectively). All the included participants underwent full history taking, full examination, routine laboratory investigations, and assessment of serum UA. Results Serum UA level in group 1 was significantly increased compared with group 2 (P = 0.000). There was a significant increased value of serum UA in group 1c compared with group 1b and group 1a (P = 0.000). In group 1, there was a significant positive correlation between serum UA level and each of age, duration of disease, and psoriasis area severity index score (P = 0.023, 0.017, and 0.002, respectively). Conclusion There was a strong association between hyperuricemia and psoriasis. Serum UA should be assessed in patients with psoriasis. Moreover, detection of high levels of serum UA may enable earlier use of preventive measures for metabolic disturbances in psoriatic patients.

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