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Subject Area

Clinical Pathology

Article Type

Original Study

Abstract

Objectives To study the clinical significance of rs1046282 polymorphism of excision-repair cross-complementation group 1 (ERCC1) as a risk factor for hepatocellular carcinoma (HCC). Background HCC is considered one of the commonest malignancies in the world. ERCC1 gene is implicated in the base-excision repair of DNA. Different polymorphisms in the ERCC1 gene were associated with ovarian, colorectal, gastric, and lung cancers. Patients and methods This case–control study was performed on 100 patients divided into three groups: HCC group, cirrhosis group, and control group. Genotypes of rs1046282 (T/C) single-nucleotide polymorphism in ERCC1 were evaluated via TaqMan allelic discrimination. Logistic regression analysis and the χ2 test were used to relate between different genotypes and the vulnerability of HCC. Results The genotype distribution was in accordance with the Hardy–Weinberg equilibrium. There was a significant statistical difference between the cirrhosis and HCC group regarding genotype distribution (P = 0.021) as the CC genotype was more represented in the HCC group than the cirrhosis group. Also, C allele was significantly more represented in HCC than the cirrhosis group (P = 0.047). The C allele and CC genotype were considerably related with elevated risk of developing HCC (P = 0.001, 0.043, respectively). Conclusion The CC genotype and C allele of ERCC1 gene single-nucleotide polymorphism rs1046282 confer susceptibility for HCC.

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