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Subject Area

Ophthalmology

Article Type

Original Study

Abstract

Objective To evaluate the changes in corneal and lenticular density following corneal cross-linking (CXL) with conventual versus enhanced protocol. Background Corneal stromal haze is common after CXL. This is related to the corneal stromal changes occurring after CXL. This can be detected clinically and graded subjectively at the slit-lamp, or measured objectively using Scheimpflug imaging densitometry. Patients and methods This is a prospective randomized controlled clinical trial including all patients with keratoconus undergoing CXL. It included 20 eyes with conventional versus 20 eyes with enhanced method. All patients attended the outpatient clinic unit of Menoufia University Hospital, Shebin El Kom, during the period study from August 2019 till June 2020. Full history; routine, physical examination; general topography; and Pentacam imaging were done. Results Mean corneal thinnest location thickness was significantly improved after 30 min (462 ± 15.6) than 10 min (431.23 ± 92.94). There were no statistically significant differences between the two studied groups regarding corneal densitometry and lens density (P > 0.05). The correlation between thinnest location and Kmax as well as corneal and lens density did not reach statistical significance level (P > 0.05). There was an exception was in group I, where thinnest location was significantly negatively correlated with Kmax preoperatively (P = 0.008) and 1 month postoperatively (P = 0.046). Moreover, thinnest location was significantly positive correlated with corneal density 180 at 6 months postoperatively (P = 0.001). Conclusion A significant improvement in corneal thinnest location thickness was observed at the final follow-up examination after 30 min (462 ± 15.6) than 10 min (431.23 ± 92.94). Moreover, thinnest location was correlated inversely with Kmax after 1 month postoperatively. However, thinnest location was significantly positively correlated with corneal density at 6 months postoperative. In addition, a significant improvement in contrast sensitivity at the final follow-up examination after 10 min than 30 min, but the different between them did not reach statistical significance.

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